Publications

Publications

Publications

Publications

Publications

Publications

Publications

Publications

Vernal sedimentation trends in north Norwegian fjords: temporary anomaly in 234Th particulate fluxes related to Phaeocystis pouchetii proliferation

Sabine Schmidt, Sauveur Belviso, Paul Wassmann, Gérard Thouzeau, Jacqueline Stefels

(pp. 235-244, 08/03/2007)

EPOC, EPHE, PSL, UB, INSU - CNRS, CNRS, LSCE, UVSQ, INSU - CNRS, CNRS, DRF (CEA), CEA, ICOS-RAMCES, LSCE, UVSQ, INSU - CNRS, CNRS, DRF (CEA), CEA, NCFS, UiT, LEMAR, IRD, IFREMER, UBO EPE, CNRS

A genome-wide association study identifies novel risk loci for type 2 diabetes.

Robert Sladek, Ghislain Rocheleau, Johan Rung, Christian Dina, Lishuang Shen, David Serre, Philippe Boutin, Daniel Vincent, Alexandre Belisle, Samy Hadjadj, Beverley Balkau, Barbara Heude, Guillaume Charpentier, Thomas J Hudson, Alexandre Montpetit, Alexey V Pshezhetsky, Marc Prentki, Barry I Posner, David J Balding, David Meyre, Constantin Polychronakos, Philippe Froguel

Type 2 diabetes mellitus results from the interaction of environmental factors with a combination of genetic variants, most of which were hitherto unknown. A systematic search for these variants was recently made possible by the development of high-density arrays that permit the genotyping of hundreds of thousands of polymorphisms. We tested 392,935 single-nucleotide polymorphisms in a French case-control cohort. Markers with the most significant difference in genotype frequencies between cases of type 2 diabetes and controls were fast-tracked for testing in a second cohort. This identified four loci containing variants that confer type 2 diabetes risk, in addition to confirming the known association with the TCF7L2 gene. These loci include a non-synonymous polymorphism in the zinc transporter SLC30A8, which is expressed exclusively in insulin-producing beta-cells, and two linkage disequilibrium blocks that contain genes potentially involved in beta-cell development or function (IDE-KIF11-HHEX and EXT2-ALX4). These associations explain a substantial portion of disease risk and constitute proof of principle for the genome-wide approach to the elucidation of complex genetic traits.

(Nature. vol. 445, n° 0028-0836, pp. 881-5, 22/02/2007)

GMM, CNRS, EPOC, EPHE, PSL, UB, INSU - CNRS, CNRS, ELICO, ULCO, CNRS, LOB ARCACHON, UB, INSU - CNRS, CNRS, LRCCI, UJM, UJM EPE, CHU Poitiers [La Milétrie], UP11, INSERM, CHSF

Evaluation of well-balanced bore-capturing schemes for 2D wetting and drying process

Fabien Marche, Philippe Bonneton, Pierre Fabrie, Nicolas Seguin

We consider numerical solutions of the two-dimensional non-linear shallow water equations with a bed slope source term. These equations are well-suited for the study of many geophysical phenomena, including coastal engineering where wetting and drying processes are commonly observed. To accurately describe the evolution of moving shorelines over strongly varying topography, we first investigate two well-balanced methods of Godunov-type, relying on the resolution of non-homogeneous Riemann problems. But even if these schemes were previously proved to be efficient in many simulations involving occurrences of dry zones, they fail to compute accurately moving shorelines. From this, we investigate a new model, called SURF_WB, especially designed for the simulation of wave transformations over strongly varying topography. This model relies on a recent reconstruction method for the treatment of the bed-slope source term and is able to handle strong variations of topography and to preserve the steady states at rest. In addition, the use of the recent VFRoe-ncv Riemann solver leads to a robust treatment of wetting and drying phenomena. An adapted ‘second order’ reconstruction generates accurate bore-capturing abilities.This scheme is validated against several analytical solutions, involving varying topography, time dependent moving shorelines and convergences toward steady states. This model should have an impact in the prediction of 2D moving shorelines over strongly irregular topography.

(International Journal for Numerical Methods in Fluids. vol. 53, n° 0271-2091, pp. 867-894, 20/02/2007)

MAB, UB, CNRS, EPOC, EPHE, PSL, UB, INSU - CNRS, CNRS, LJLL (UMR_7598), UPD7, SU, CNRS

Evaluation of well-balanced bore-capturing schemes for 2D wetting and drying processes

F. Marche, P. Bonneton, P. Fabrie, N. Seguin

(International Journal for Numerical Methods in Fluids. vol. 53, n° 0271-2091, pp. 867-894, 20/02/2007)

EPOC, EPHE, PSL, UB, INSU - CNRS, CNRS, IMB, UB, Bordeaux INP, CNRS

Spartina anglica eradication experiment and in situ monitoring assess structuring strength of habitat complexity on marine macrofauna at high tidal level

Maud Cottet, Xavier de Montaudouin, Hugues Blanchet, Pascal Lebleu

The cordgrass Spartina anglica is an introduced species that tends to invade sheltered sand and mudflats, at the upper low marsh level. In Arcachon Bay, a lagoon in South West of France, the cordgrass can also replace Zostera noltii beds. The consequence of cordgrass presence on macrobenthic fauna was estimated and compared to adjacent habitats (bare sands, Z. noltii sea grass beds) during one year. The communities of the three habitats were characterised by low species richness, low abundance and biomass (when Hydrobia ulvae, 90% of abundance, is not considered) and high seasonal stability. The infaunal assemblages were particularly homogeneous between habitats without any characteristic species. Cordgrass eradication experiments were performed and zoobenthic recolonisation was observed the following year. Modifications in benthic fauna were observed on epifauna only. These results highlight the limited structuring effect of habitat heterogeneity at high tidal levels and in soft-bottom sediments where desiccation becomes the dominant factor determining infauna community structure.

(Estuarine, Coastal and Shelf Science. vol. 71, n° 0272-7714, pp. 629-640, 01/02/2007)

EPOC, EPHE, PSL, UB, INSU - CNRS, CNRS

Present-day and past (last 25000 years) marine pollen signal off western Iberia

F. Naughton, M.F. Sanchez Goñi, S. Desprat, J.-L. Turon, J. Duprat, B. Malaizé, C. Joli, E. Cortijo, T. Drago, M.C. Freitas

(Marine Micropaleontology. vol. 62, n° 0377-8398, pp. 91-114, 01/02/2007)

EPOC, EPHE, PSL, UB, INSU - CNRS, CNRS, LSCE, UVSQ, INSU - CNRS, CNRS, DRF (CEA), CEA, PALEOCEAN, LSCE, UVSQ, INSU - CNRS, CNRS, DRF (CEA), CEA, ULISBOA

Importance of intertidal sediment processes and porewater exchange on the water column biogeochemistry in a pristine mangrove creek (Ras Dege, Tanzania)

S. Bouillon, J. J. Middelburg, F. Dehairs, A. V. Borges, G. Abril, M. R. Flindt, S. Ulomi, E. Kristensen

We conducted diurnal sampling in a tidal creek (Ras Dege, Tanzania) to document the variations in a suite of creek water column characteristics and to determine the relative influence of tidal and biological driving forces. Since the creek has no upstream freshwater inputs, highest salinity was observed at low tide, due to evaporation effects and porewater seepage. Total suspended matter (TSM) and particulate organic carbon (POC) showed distinct maxima at periods of highest water flow, indicating that erosion of surface sediments and/or resuspension of bottom sediments were an important source of particulate material. Dissolved organic carbon (DOC), in contrast, followed the tidal variations and was highest at low tide. Stable isotope data of POC and DOC exhibit large variations in both pools, and followed tidal variations. Although the variation of d13CDOC (-23.8 to -13.8‰) was higher than that of d13CPOC (-26.2 to -20.5‰) due to the different end-member pool sizes, the d13C signatures of both pools differed only slightly at low tide, but up to 9‰ at high tide. Thus, at low tide both DOC and POC originated from mangrove production. At high tide, on the other hand, the DOC pool had signatures consistent with a high contribution of seagrass-derived material, whereas the POC pool was dominated by marine phytoplankton. Daily variations in CH4, and partial pressure of CO2 (pCO2) were similarly governed by tidal influence and were up to 7- and 10-fold higher at low tide, which stresses the importance of exchange of porewater and diffusive fluxes to the water column. Furthermore, this illustrates that constraining an ecosystem-level budget of these greenhouse gases in tidal systems requires a careful appraisal of tidal variations. When assuming that the high dissolved inorganic carbon (DIC) levels in the upper parts of the creek (i.e. at low tide) are due to inputs from mineralization, d13C data on DIC indicate that the source of the mineralized organic matter has a signature of -22.4‰, which shows that imported POC and DOC from the marine environment contributes strongly to overall mineralization within the mangrove system. Our data show a striking example of how biogeochemical processes in the intertidal zone appear to be prominent drivers of element concentrations and isotope signatures in the water column, and how pathways of dissolved and particulate matter exchange are fundamentally different. The estimated export of DIC through porewater exchange appears considerably larger than for DOC, suggesting that if this mechanism is indeed a major driver of solute exchange, benthic mineralization and subsequent export as DIC could represent a very significant and previously unaccounted fate of mangrove-derived C. Budgeting efforts should therefore pay attention to understanding the mechanisms and quantification of different pathways of exchange within and between both zones.

(Biogeosciences Discussions. vol. 4, n° 1810-6277, pp. 317-348, 31/01/2007)

VUB, NIOO-KNAW, ULiège, EPOC, EPHE, PSL, UB, INSU - CNRS, CNRS

Anomalous flow below 2700 m in the EPICA Dome C ice core detected using d18O of atmospheric oxygen measurements

G. B. Dreyfus, F. Parrenin, B. Lemieux-Dudon, Geoffroy Durand, Valérie Masson-Delmotte, Jean Jouzel, J.-M. Barnola, L. Panno, R. Spahni, A. Tisserand, U. Siegenthaler, M. Leuenberger

While there are no indications of mixing back to 800 000 years in the EPICA Dome C ice core record, comparison with marine sediment records shows significant differences in the timing and duration of events prior to stage 11 (~430 ka, thousand of years before 1950). A relationship between the isotopic composition of atmospheric oxygen (d18O of O2, noted d18Oatm) and daily northern hemisphere summer insolation has been observed for the youngest four climate cycles. Here we use this relationship with new d18O of O2 measurements to show that anomalous flow in the bottom 500 m of the core distorts the duration of events by up to a factor of 2. By tuning d18Oatm to orbital precession we derive a corrected thinning function and present a revised age scale for the interval corresponding to Marine Isotope Stages 11–20 in the EPICA Dome C ice core. Uncertainty in the phasing of d18Oatm with respect to insolation variations in the precession band limits the accuracy of this new agescale to ±6 kyr (thousand of years). The previously reported ~30 kyr duration of interglacial stage 11 is unchanged. In contrast, the duration of stage 15.1 is reduced by a factor of 2, from 31 to 16 kyr.

(pp. 63-93, 16/01/2007)

LSCE, UVSQ, INSU - CNRS, CNRS, DRF (CEA), CEA, GLACCIOS, LSCE, UVSQ, INSU - CNRS, CNRS, DRF (CEA), CEA, LGGE, OSUG, UJF, Grenoble INP, INSU - CNRS, IRSTEA, USMB [Université de Savoie] [Université de Chambéry], CNRS, INSU - CNRS, CNRS, NBI, UCPH, EPOC, EPHE, PSL, UB, INSU - CNRS, CNRS

Climate variability of the last five isotopic interglacials: Direct land-sea-ice correlation from the multiproxy analysis of North-Western Iberian margin deep-sea cores

S. Desprat, M.F. Sánchez Goñi, F. Naughton, J.-L. Turon, J. Duprat, B. Malaizé, E. Cortijo, J.-P. Peypouquet

(pp. 375-386 (chapter 25), 26/10/2026)

EPOC, EPHE, PSL, UB, INSU - CNRS, CNRS, LSCE, UVSQ, INSU - CNRS, CNRS, DRF (CEA), CEA, PALEOCEAN, LSCE, UVSQ, INSU - CNRS, CNRS, DRF (CEA), CEA

Influence of the parasite worm Polydora sp. on the behaviour of the oyster Crassostrea gigas: a study of the respiratory impact and associated oxidative stress

Caroline Chambon, Alexia Legeay, Gilles Durrieu, Patrice Gonzalez, Pierre Ciret, Jean-Charles Massabuau

The aim of this study was to investigate how the worm Polydora sp., which induces oysters into creating mud blisters in response to an irritation within their shells, could interfere with the oyster Crassostrea gigas physiology and ethology. The impact was characterized by studying two groups of oysters (non-parasitized and parasitized) during a 30 days period: (1) the animal behaviour by analysing their valve activity (valvometry), and (2) the animal respiratory physiology by measuring in vivo the oxygen partial pressure and the specific oxygen consumption in selected tissues (heart, fast and slow adductor muscle). We also researched a putative impact on the expression of several oxidative stress genes at the heart level. Our results show that Polydora sp. is clearly an oyster’s parasite as it induces a decrease in oyster growth according to the infestation intensity. Moreover, it modifies the behaviour and the respiratory physiology of the molluscs. Infested animals opened more frequently but for less time and their level of blood oxygenation was systematically higher than healthy molluscs. These high levels of oxygenation had no effect on the oxidative metabolism of the tissues studied but they induced oxidative stress. Indeed, the superoxide dismutase gene showed a threefold increase in expression in the heart of infested oysters. A putative scenario of the weakening mechanism is proposed.

(Marine Biology. vol. 152, n° 0025-3162, pp. 329-338, 26/10/2026)

EPOC, EPHE, PSL, UB, INSU - CNRS, CNRS